Identification of highly conserved regions in L-segment of Crimean–Congo hemorrhagic fever virus and immunoinformatic prediction about potential novel vaccine
Identifieur interne : 001083 ( Main/Exploration ); précédent : 001082; suivant : 001084Identification of highly conserved regions in L-segment of Crimean–Congo hemorrhagic fever virus and immunoinformatic prediction about potential novel vaccine
Auteurs : Arafat Rahman Oany [Bangladesh] ; Shah Adil Ishtiyaq Ahmad [Bangladesh] ; Mohammad Uzzal Hossain [Bangladesh] ; Tahmina Pervin Jyoti [Bangladesh]Source :
- Advances and Applications in Bioinformatics and Chemistry : AABC [ 1178-6949 ] ; 2015.
Abstract
Crimean–Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic viral disease with a disease fatality rate between 15% and 70%. Despite the wide range of distribution, the virus (CCHFV) is basically endemic in Africa, Asia, eastern Europe, and the Middle East. Acute febrile illness associated with petechiae, disseminated intravascular coagulation, and multiple-organ failure are the main symptoms of the disease. With all these fatal effects, CCHFV is considered a huge threat as no successful therapeutic approach is currently available for the treatment of this disease. In the present study, we have used the immunoinformatics approach to design a potential epitope-based vaccine against the RNA-dependent RNA polymerase-L of CCHFV. Both the T-cell and B-cell epitopes were assessed, and the epitope “DCSSTPPDR” was found to be the most potential one, with 100% conservancy among all the strains of CCHFV. The epitope was also found to interact with both type I and II major histocompatibility complex molecules and is considered nonallergenic as well. In vivo study of our proposed peptide is advised for novel universal vaccine production, which might be an effective path to prevent CCHF disease.
Url:
DOI: 10.2147/AABC.S75250
PubMed: 25609983
PubMed Central: 4293217
Affiliations:
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type="main">Identification of highly conserved regions in L-segment of Crimean–Congo hemorrhagic fever virus and immunoinformatic prediction about potential novel vaccine</title><author><name sortKey="Oany, Arafat Rahman" sort="Oany, Arafat Rahman" uniqKey="Oany A" first="Arafat Rahman" last="Oany">Arafat Rahman Oany</name><affiliation wicri:level="1"><nlm:aff id="af1-aabc-8-001">Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail</wicri:regionArea><wicri:noRegion>Tangail</wicri:noRegion></affiliation></author><author><name sortKey="Ahmad, Shah Adil Ishtiyaq" sort="Ahmad, Shah Adil Ishtiyaq" uniqKey="Ahmad S" first="Shah Adil Ishtiyaq" last="Ahmad">Shah Adil Ishtiyaq Ahmad</name><affiliation wicri:level="1"><nlm:aff id="af1-aabc-8-001">Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail</wicri:regionArea><wicri:noRegion>Tangail</wicri:noRegion></affiliation></author><author><name sortKey="Hossain, Mohammad Uzzal" sort="Hossain, Mohammad Uzzal" uniqKey="Hossain M" first="Mohammad Uzzal" last="Hossain">Mohammad Uzzal Hossain</name><affiliation wicri:level="1"><nlm:aff id="af1-aabc-8-001">Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail</wicri:regionArea><wicri:noRegion>Tangail</wicri:noRegion></affiliation></author><author><name sortKey="Jyoti, Tahmina Pervin" sort="Jyoti, Tahmina Pervin" uniqKey="Jyoti T" first="Tahmina Pervin" last="Jyoti">Tahmina Pervin Jyoti</name><affiliation wicri:level="1"><nlm:aff id="af2-aabc-8-001">Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna, Bangladesh</nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna</wicri:regionArea><wicri:noRegion>Khulna</wicri:noRegion></affiliation></author></analytic><series><title level="j">Advances and Applications in Bioinformatics and Chemistry : AABC</title><idno type="eISSN">1178-6949</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Crimean–Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic viral disease with a disease fatality rate between 15% and 70%. Despite the wide range of distribution, the virus (CCHFV) is basically endemic in Africa, Asia, eastern Europe, and the Middle East. Acute febrile illness associated with petechiae, disseminated intravascular coagulation, and multiple-organ failure are the main symptoms of the disease. With all these fatal effects, CCHFV is considered a huge threat as no successful therapeutic approach is currently available for the treatment of this disease. In the present study, we have used the immunoinformatics approach to design a potential epitope-based vaccine against the RNA-dependent RNA polymerase-L of CCHFV. Both the T-cell and B-cell epitopes were assessed, and the epitope “DCSSTPPDR” was found to be the most potential one, with 100% conservancy among all the strains of CCHFV. The epitope was also found to interact with both type I and II major histocompatibility complex molecules and is considered nonallergenic as well. In vivo study of our proposed peptide is advised for novel universal vaccine production, which might be an effective path to prevent CCHF disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cunha, Ba" uniqKey="Cunha B">BA Cunha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmaljohn, C" uniqKey="Schmaljohn C">C Schmaljohn</name></author><author><name sortKey="Hooper, J" uniqKey="Hooper J">J Hooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lacy, Md" uniqKey="Lacy M">MD Lacy</name></author><author><name sortKey="Smego, R" uniqKey="Smego R">R Smego</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ergonul, O" uniqKey="Ergonul O">Ö Ergönül</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ergonul, O" uniqKey="Ergonul O">O 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Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lapelosa, M" uniqKey="Lapelosa M">M Lapelosa</name></author><author><name sortKey="Gallicchio, E" uniqKey="Gallicchio E">E Gallicchio</name></author><author><name sortKey="Arnold, Gf" uniqKey="Arnold G">GF Arnold</name></author><author><name sortKey="Arnold, E" uniqKey="Arnold E">E Arnold</name></author><author><name sortKey="Levy, Rm" uniqKey="Levy R">RM Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chakraborty, S" uniqKey="Chakraborty S">S Chakraborty</name></author><author><name sortKey="Chakravorty, R" uniqKey="Chakravorty R">R Chakravorty</name></author><author><name sortKey="Ahmed, M" uniqKey="Ahmed M">M Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oany, Ar" uniqKey="Oany A">AR Oany</name></author><author><name sortKey="Emran, Aa" uniqKey="Emran A">AA Emran</name></author><author><name sortKey="Jyoti, Tp" uniqKey="Jyoti T">TP Jyoti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, Mk" uniqKey="Khan M">MK Khan</name></author><author><name sortKey="Zaman, S" uniqKey="Zaman S">S Zaman</name></author><author><name sortKey="Chakraborty, S" uniqKey="Chakraborty S">S Chakraborty</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Bangladesh</li></country></list><tree><country name="Bangladesh"><noRegion><name sortKey="Oany, Arafat Rahman" sort="Oany, Arafat Rahman" uniqKey="Oany A" first="Arafat Rahman" last="Oany">Arafat Rahman Oany</name></noRegion><name sortKey="Ahmad, Shah Adil Ishtiyaq" sort="Ahmad, Shah Adil Ishtiyaq" uniqKey="Ahmad S" first="Shah Adil Ishtiyaq" last="Ahmad">Shah Adil Ishtiyaq Ahmad</name><name sortKey="Hossain, Mohammad Uzzal" sort="Hossain, Mohammad Uzzal" uniqKey="Hossain M" first="Mohammad Uzzal" last="Hossain">Mohammad Uzzal Hossain</name><name sortKey="Jyoti, Tahmina Pervin" 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